diff --git a/Marlin/twibus.cpp b/Marlin/twibus.cpp
index d17648cec..c1d6008dd 100644
--- a/Marlin/twibus.cpp
+++ b/Marlin/twibus.cpp
@@ -42,25 +42,26 @@ void TWIBus::reset() {
 void TWIBus::address(uint8_t addr) {
   this->addr = addr;
 
-  if (DEBUGGING(INFO)) {
-    SERIAL_ECHOPAIR("TWIBus::sendto: ", this->addr);
-    SERIAL_EOL;
-  }
+  #if ENABLED(DEBUG_TWIBUS)
+    debug(PSTR("sendto"), this->addr);
+  #endif
 }
 
 void TWIBus::addbyte(char c) {
   if (buffer_s >= sizeof(this->buffer)) return;
   this->buffer[this->buffer_s++] = c;
 
-  if (DEBUGGING(INFO)) {
-    SERIAL_ECHOPAIR("TWIBus::addbyte: ", this->buffer[this->buffer_s -1]);
-    SERIAL_EOL;
-  }
+  #if ENABLED(DEBUG_TWIBUS)
+    debug(PSTR("addbyte"), this->buffer[this->buffer_s - 1]);
+  #endif
 }
 
 void TWIBus::send() {
   if (!this->addr) return;
-  if (DEBUGGING(INFO)) SERIAL_ECHOLNPGM("TWIBus::send()");
+
+  #if ENABLED(DEBUG_TWIBUS)
+    debug(PSTR("send()"));
+  #endif
 
   Wire.beginTransmission(this->addr);
   Wire.write(this->buffer, this->buffer_s);
@@ -72,10 +73,10 @@ void TWIBus::send() {
 
 void TWIBus::reqbytes(uint8_t bytes) {
   if (!this->addr) return;
-  if (DEBUGGING(INFO)) {
-    SERIAL_ECHOPAIR("TWIBus::reqbytes(): ", bytes);
-    SERIAL_EOL;
-  }
+
+  #if ENABLED(DEBUG_TWIBUS)
+    debug(PSTR("reqbytes"), bytes);
+  #endif
 
   millis_t t = millis() + this->timeout;
   Wire.requestFrom(this->addr, bytes);
@@ -101,4 +102,17 @@ void TWIBus::reqbytes(uint8_t bytes) {
   this->reset();
 }
 
+#if ENABLED(DEBUG_TWIBUS)
+
+  void TWIBus::debug(const char func[], int32_t val/*=-1*/) {
+    if (DEBUGGING(INFO)) {
+      SERIAL_ECHOPGM("TWIBus::");
+      serialprintPGM(func);
+      if (val >= 0) SERIAL_ECHOPAIR(": ", val);
+      SERIAL_EOL;
+    }
+  }
+
+#endif
+
 #endif //EXPERIMENTAL_I2CBUS
diff --git a/Marlin/twibus.h b/Marlin/twibus.h
index 5ab725777..d0d0e0ff3 100644
--- a/Marlin/twibus.h
+++ b/Marlin/twibus.h
@@ -23,6 +23,11 @@
 #ifndef TWIBUS_H
 #define TWIBUS_H
 
+#include "macros.h"
+
+// Print debug messages with M111 S2 (Uses 236 bytes of PROGMEM)
+//#define DEBUG_TWIBUS
+
 /**
  * TWIBUS class
  *
@@ -117,6 +122,16 @@ class TWIBus {
      * @param bytes the number of bytes to request
      */
     void reqbytes(uint8_t bytes);
+
+    #if ENABLED(DEBUG_TWIBUS)
+
+      /**
+       * @brief Prints a debug message
+       * @details Prints a simple debug message "TWIBus::function: value"
+       */
+      static void debug(const char func[], int32_t val = -1);
+
+    #endif
 };
 
 #endif //TWIBUS_H